On December 5, 2024, professor Qipeng Yuan & Jia Wang's research group in Beijing University of Chemical Technology (BUCT) published a research paper entitled“A bacterial platform for producing aromatic esters from glycerol“ in Nature Chemical Engineering.
Aromatic ester compounds are widely used in flavor, fragrance, cosmetics, pharmaceuticals, food and beverage industries. This study establishes a microbial platform for the efficient production of various aromatic esters. A systematic engineering strategy was developed, involving reshaping the substrate access tunnel to enhance enzyme substrate specificity, shifting acetyl coenzyme A metabolic pathways to improve cofactor supply and engineering a dynamic regulation system to redistribute the carbon flux from cell growth toward product synthesis. This work showcases a bacterial platform for the efficient production of aromatic esters and offers insights into overcoming challenges in microbial cell factory construction.
The first author of the paper is Liangyu Lu, a PhD student in Beijing Advanced Innovation Center for Soft Matter Science and Engineering, and the corresponding authors are Professors Qipeng Yuan and Jia Wang in College of Life Science and Technology.
Original link：https://www.nature.com/articles/s44286-024-00148-9